Imagine where we would be today if medical science for the last 60 years had concerned itself only with treating symptoms. Yet, this is what the science and practice of business transformation has been doing since the 1980s. Three quarters of major change – turnarounds, spinoffs, new business models, M&A, digital /AI transformations, etc. – fall short of objectives. One main reasons is culture. The way we approach culture focuses on symptoms rather than their cause, based on outmoded ideas about people, values, and behavior. In this address Dr. White shows how cultural neuroscience makes real culture change possible with surprising insights that can revolutionize how leaders achieve business transformations success.